PUBLICATIONS
Choi EK, Aring L, Peng Y, Correia AB, Lieberman AP, Iwase S, and Seo YA*. Neuronal SLC39A8 deficiency impairs cerebellar development by altering manganese homeostasis. JCI Insight 2024 Accepted for Publication.
Choi EK, Rajendiran TM, Soni T, Park JH, Aring L, Muraleedharan CK, Garcia-Hernandez V, Kamada N, Samuelson LC, Nusrat A, Iwase S, and Seo YA*. The manganese transporter SLC39A8 links alkaline ceramidase 1 to inflammatory bowel disease. Nature Communications 2024 Jun 5;15(1):4775. Link PDF
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Blake AD, Chao J, SantaMaria AM, Ekaputri S, Green KJ, Brown ST, Rakowski CK, Choi EK, Aring L, Chen PJ, Snead NM, Matje DM, Geng T, Octaviani A, Bailey K, Hollenbach SJ, Fan TM, Seo YA*, Burke MD*. Minimizing higher-order aggregation maximizes iron mobilization by small molecules. Nature Chemical Biology 2024 doi: 10.1038/s41589-024-01596-3 Link PDF
Kumar A, Ye C, Nkansah A, Decoville T, Fogo GM, Sajjakulnukit P, Reynolds MB, Zhang L, Quaye O, Seo YA, Sanderson TH, Lyssiotis CA, Chang CH. Iron regulates the quiescence of naive CD4 T cells by controlling mitochondria and cellular metabolism. Proceedings of the National Academy of Sciences of the U.S.A 2024;121(17):e2318420121. doi: 10.1073/pnas.2318420121. Link PDF
Yang CL, Leung CW, Lee JT, Park SK, Jansen EC, Seo YA*. Manganese and Sleep Outcomes in United States Adults: Results from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). Journal of Nutrition. 2024;154(1):213-223. doi.org/10.1016/j.tjnut.2023.11.012. Link PDF
Kim S, Seo YA*. In vitro studies of manganese transport and homeostasis. Methods in Enzymology. 2023;687:185-206. doi: 10.1016/bs.mie.2023.04.023. Link PDF
Ekaputri S, Choi EK, Sabelli M, Aring L, Green KJ, Chang JO, Bao K, Choi HS, Iwase S, Kim J, Corradini E, Pietragenlo A*, Burke MD*, Seo YA*. A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages. Proceedings of the National Academy of Sciences of the U.S.A 2022;119(26):e2121400119. doi.org/10.1073/pnas.2121400119. *Co-corresponding author Link PDF
Aring L, Choi EK, Kopera H, Lanigan T, Iwase S, Klionsky DJ, Seo YA*. A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation. Journal of Neurochemistry 2022;160(3):356-375. doi: 10.1111/jnc.15548. Link PDF
This article is highlighted on the cover of Journal of Neurochemistry. Cover image: https://doi.org/10.1111/jnc.15388
This article is highlighted in the newsletter from NBIA (Neurodegeneration with Brain Iron Accumulation) Disorders Association. [News]
Wang X, Seo YA, Park SK. Serum selenium and non-alcoholic fatty liver disease (NAFLD) in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2011-2016. Environmental Research 2021;197:111190. Link PDF
Seo YA*, Choi EK, Aring L, Paschall M, Iwase S. Transcriptome analysis of the cerebellum of mice fed a manganese-deficient diet. Frontiers in Genetics 2020;11:558725. Link PDF
Kho M, Smith JA, Verweij N, Shang L, Ryan KA, Zhao W, Ware EB, Gansevoort RT, Irvin MR, Lee JE, Turner ST, Sung J, van der Harst P, Arnett DK, Baylin A, Park SK, Seo YA, Kelly KM, Chang YPC, Zhou X, Lieske JC, Kardia SLR. Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies Suggestive Loci for Sodium Intake, Potassium Intake, and Their Ratio Measured from 24-Hour or Half-Day Urine Samples. Journal of Nutrition 2020;12; 150(10);2635-2645 Link PDF
Bakulski KM*, Seo YA*, Hickman RC, Brandt D, Vadari HS, Hu H, Park SK. Heavy Metal Exposure and Alzheimer’s Disease and Related Dementias. Journal of Alzheimer’s Disease 2020;76(4):1215-1242. *Co-first author Link PDF
Vallianatos CN, Raines B, Porter RS, Bonefas KM, Wu MC, Garay PM, Collette KM, Seo YA, Dou Y, Keegan CE, Tronson NC, Iwase S. Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation. Communications Biology 2020;1;3(1):278. Link PDF
Yarosz EL, Ye C, Kumar A, Black C, Choi EK, Seo YA*, Chang CH*. Cutting Edge: Activation-Induced Iron Flux Controls CD4 T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial Function. Journal of Immunology 2020;1;204(7):1708-1713. *Co-corresponding author Link PDF
Choi EK, Aring L, Das NK, Solanki S, Inohara N, Iwase S, Samuelson LC, Shah YM, Seo YA. Impact of dietary manganese in experimental colitis in mice. FASEB journal 2020;34(2):2929-2943 Link PDF
Choi EK, Nguyen TT, Iwase S, Seo YA. Ferroportin disease mutations influence manganese accumulation and cytotoxicity. FASEB journal 2019;33(2):2228-2240 Link PDF
Choi EK, Nguyen TT, Gupta N, Iwase S, Seo YA. Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders. Scientific Reports 2018;16;8(1):3163. Link PDF
Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science 2017;356(6338):608-616. Link PDF
Seo YA, Kumara R, Wetli H, Wessling-Resnick M. Regulation of divalent metal transporter-1 by serine phosphorylation. Biochemical Journal 2016;473(22):4243-4254. PMC5103878 Link PDF
Patchen B, Koppe T, Cheng A, Seo YA, Wessling-Resnick M, Fraenkel PG. Dietary supplementation with ipriflavone decreases hepatic iron stores in wild type mice. Blood Cells, Molecules and Diseases 2016;60:36-43. PMC5094460 Link PDF
Seo YA*, Elkhader JA, and Wessling-Resnick M*. Manganese and other metals distribution in flatiron mice. Biometals 2016;29(1):147-55. PMC4735247 *Co-corresponding author Link PDF
Seo YA and Wessling-Resnic M. Ferroportin deficiency impairs manganese metabolism in flatiron mice. FASEB Journal 2015;29(7):2726-33. PMC4478796 Link PDF
Hennigar SR, Seo YA, Sharma S, Soybel DI, and Kelleher SL. ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution. Scientific Reports 2015;5:8033 PMC4306139 Link PDF
Seo YA, Lee S, Hennigar SR, and Kelleher SL. Prolactin-stimulated ubiquitination of ZnT2 mediates a transient increase in Zn secretion followed by ZnT2 degradation in mammary epithelial cells. Journal of Biological Chemistry 2014;289(34):23653-61. PMC4156067 Link PDF
Seo YA, Li Y, Wessling-Resnick M. Iron depletion increases manganese uptake and potentiates apoptosis through ER stress. Neurotoxicology 2013;38C:67-73. PMC3770814 Link PDF
Lasry I*, Seo YA*, Ityel H, Shalva N, Pode-Shakked B, Glaser F, Berman B, Berezovsky I, Goncearenco A, Klar A, Levy J, Anikster Y, Kelleher SL, Assaraf YG. A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency. Journal of Biological Chemistry 2012;287(35):29348-61. PMC3436150 *Co-first authors. Link PDF
Dempsey C, McCormick NH, Croxford TP, Seo YA, Grider A, and Kelleher SL. Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition. Journal of Nutrition 2011;142(4):655-60. PMC3301987 Link PDF
Seo YA, Lopez V, Kelleher SL. A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function. American Journal of Physiology Cell Physiology 2011;300: C1479-89. PMC3118624 Link PDF
Seo YA, Kelleher SL. Functional analysis of two single nucleotide polymorphisms in SLC30A2 (ZnT2): implications for mammary gland function and breast disease in women. Physiological Genomics 2010;42A: 219-27. PMC3008367 Link PDF
Qian L, Lopez V, Seo YA, Kelleher SL. Prolactin regulates ZnT2 expression through the JAK2/STAT5 signaling pathway in mammary cells. American Journal of Physiology Cell Physiology 2009;297: C369-77. PMC2724096 Link PDF
Kelleher SL, Seo YA, Lopez V. Mammary gland zinc metabolism: regulation and dysregulation. Genes and Nutrition 2009;4: 83-94. PMC2690727 Link PDF
Choi EK, Rajendiran TM, Soni T, Park JH, Aring L, Muraleedharan CK, Garcia-Hernandez V, Kamada N, Samuelson LC, Nusrat A, Iwase S, and Seo YA. The manganese transporter SLC39A8 links alkaline ceramidase 1 to inflammatory bowel disease. Nature Communications 2024 Jun 5;15(1):4775. Link PDF
Blake AD, Chao J, SantaMaria AM, Ekaputri S, Green KJ, Brown ST, Rakowski CK, Choi EK, Aring L, Chen PJ, Snead NM, Matje DM, Geng T, Octaviani A, Bailey K, Hollenbach SJ, Fan TM, Seo YA*, Burke MD*. Minimizing higher-order aggregation maximizes iron mobilization by small molecules. Nature Chemical Biology 2024 doi: 10.1038/s41589-024-01596-3 *Co-corresponding author Link PDF
Kumar A, Ye C, Nkansah A, Decoville T, Fogo GM, Sajjakulnukit P, Reynolds MB, Zhang L, Quaye O, Seo YA, Sanderson TH, Lyssiotis CA, Chang CH. Iron regulates the quiescence of naive CD4 T cells by controlling mitochondria and cellular metabolism. Proceedings of the National Academy of Sciences of the U.S.A 2024;121(17):e2318420121. doi: 10.1073/pnas.2318420121. Link PDF
Yang CL, Leung CW, Lee JT, Park SK, Jansen EC, Seo YA. Manganese and Sleep Outcomes in United States Adults: Results from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). Journal of Nutrition. 2024;154(1):213-223. doi.org/10.1016/j.tjnut.2023.11.012. Link PDF
Kim S, Seo YA. In vitro studies of manganese transport and homeostasis. Methods in Enzymology. 2023;687:185-206. doi: 10.1016/bs.mie.2023.04.023. Link PDF
Ekaputri S, Choi EK, Sabelli M, Aring L, Green KJ, Chang JO, Bao K, Choi HS, Iwase S, Kim J, Corradini E, Pietragenlo A*, Burke MD*, Seo YA*. A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages. Proceedings of the National Academy of Sciences of the U.S.A 2022;119(26):e2121400119. doi.org/10.1073/pnas.2121400119. *Co-corresponding author Link PDF
Aring L, Choi EK, Kopera H, Lanigan T, Iwase S, Klionsky DJ, Seo YA. A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation. Journal of Neurochemistry 2022;160(3):356-375. doi: 10.1111/jnc.15548. Link PDF
This article is highlighted on the cover of Journal of Neurochemistry. Cover image: https://doi.org/10.1111/jnc.15388
This article is highlighted in the newsletter from NBIA (Neurodegeneration with Brain Iron Accumulation) Disorders Association. [News]
Wang X, Seo YA, Park SK. Serum selenium and non-alcoholic fatty liver disease (NAFLD) in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2011-2016. Environmental Research 2021;197:111190. Link PDF
Seo YA, Choi EK, Aring L, Paschall M, Iwase S. Transcriptome analysis of the cerebellum of mice fed a manganese-deficient diet. Frontiers in Genetics 2020;11:558725. Link PDF
Kho M, Smith JA, Verweij N, Shang L, Ryan KA, Zhao W, Ware EB, Gansevoort RT, Irvin MR, Lee JE, Turner ST, Sung J, van der Harst P, Arnett DK, Baylin A, Park SK, Seo YA, Kelly KM, Chang YPC, Zhou X, Lieske JC, Kardia SLR. (2020) Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies Suggestive Loci for Sodium Intake, Potassium Intake, and Their Ratio Measured from 24-Hour or Half-Day Urine Samples. Journal of Nutrition 12; 150(10);2635-2645 [Pubmed]
Bakulski KM*, Seo YA*, Hickman RC, Brandt D, Vadari HS, Hu H, Park SK. (2020) Heavy Metal Exposure and Alzheimer’s Disease and Related Dementias. Journal of Alzheimer’s Disease 76(4):1215-1242. [Pubmed] *Co-first author
Vallianatos CN, Raines B, Porter RS, Bonefas KM, Wu MC, Garay PM, Collette KM, Seo YA, Dou Y, Keegan CE, Tronson NC, Iwase S. (2020) Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation. Communications Biology 1;3(1):278. [Pubmed]
Yarosz EL, Ye C, Kumar A, Black C, Choi EK, Seo YA*, Chang CH*. (2020) Cutting Edge: Activation-Induced Iron Flux Controls CD4 T Cell Proliferation by Promoting Proper IL-2R Signaling and Mitochondrial Function. Journal of Immunology 1;204(7):1708-1713. [Pubmed] *Co-corresponding author
Choi EK, Aring L, Das NK, Solanki S, Inohara N, Iwase S, Samuelson LC, Shah YM, Seo YA. (2020) Impact of dietary manganese in experimental colitis in mice. FASEB journal 34(2):2929-2943 [Pubmed]
Choi EK, Nguyen TT, Iwase S, Seo YA. (2019) Ferroportin disease mutations influence manganese accumulation and cytotoxicity. FASEB journal 33(2):2228-2240 [Pubmed]
Choi EK, Nguyen TT, Gupta N, Iwase S, Seo YA. (2018) Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders. Scientific Reports 16;8(1):3163.[Pubmed]
Grillo AS, SantaMaria AM, Kafina MD, Cioffi AG, Huston NC, Han M, Seo YA, Yien YY, Nardone C, Menon AV, Fan J, Svoboda DC, Anderson JB, Hong JD, Nicolau BG, Subedi K, Gewirth AA, Wessling-Resnick M, Kim J, Paw BH, Burke MD. (2017) Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science 356(6338):608-616.[Pubmed]
Seo YA, Kumara R, Wetli H, Wessling-Resnick M. (2016) Regulation of divalent metal transporter-1 by serine phosphorylation. Biochemical Journal 473(22):4243-4254. PMC5103878 [Pubmed]
Patchen B, Koppe T, Cheng A, Seo YA, Wessling-Resnick M, Fraenkel PG. (2016) Dietary supplementation with ipriflavone decreases hepatic iron stores in wild type mice. Blood Cells, Molecules and Diseases 60:36-43. PMC5094460 Link PDF
Seo YA*, Elkhader JA, and Wessling-Resnick M*. (2016) Manganese and other metals distribution in flatiron mice. Biometals 29(1):147-55. PMC4735247 *Co-corresponding author Link PDF
Seo YA and Wessling-Resnic M. (2015) Ferroportin deficiency impairs manganese metabolism in flatiron mice. FASEB Journal 29(7):2726-33. PMC4478796 Link PDF
Hennigar SR, Seo YA, Sharma S, Soybel DI, and Kelleher SL. (2015) ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution. Scientific Reports 5:8033 PMC4306139 Link PDF
Seo YA, Lee S, Hennigar SR, and Kelleher SL. (2014) Prolactin-stimulated ubiquitination of ZnT2 mediates a transient increase in Zn secretion followed by ZnT2 degradation in mammary epithelial cells. Journal of Biological Chemistry 289(34):23653-61. PMC4156067 Link PDF
Seo YA, Li Y, Wessling-Resnick M. (2013) Iron depletion increases manganese uptake and potentiates apoptosis through ER stress. Neurotoxicology 38C:67-73. PMC3770814 Link PDF
Lasry I*, Seo YA*, Ityel H, Shalva N, Pode-Shakked B, Glaser F, Berman B, Berezovsky I, Goncearenco A, Klar A, Levy J, Anikster Y, Kelleher SL, Assaraf YG. (2012) A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency. Journal of Biological Chemistry 287(35):29348-61. PMC3436150 *Co-first authors. Link PDF
Dempsey C, McCormick NH, Croxford TP, Seo YA, Grider A, and Kelleher SL. (2011) Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition. Journal of Nutrition 142(4):655-60. PMC3301987 Link PDF
Seo YA, Lopez V, Kelleher SL. (2011) A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function. American Journal of Physiology Cell Physiology 300: C1479-89. PMC3118624 Link PDF
Seo YA, Kelleher SL. (2010) Functional analysis of two single nucleotide polymorphisms in SLC30A2 (ZnT2): implications for mammary gland function and breast disease in women. Physiological Genomics 42A: 219-27. PMC3008367 Link PDF
Qian L, Lopez V, Seo YA, Kelleher SL. (2009) Prolactin regulates ZnT2 expression through the JAK2/STAT5 signaling pathway in mammary cells. American Journal of Physiology Cell Physiology 297: C369-77. PMC2724096 Link PDF
Kelleher SL, Seo YA, Lopez V. (2009) Mammary gland zinc metabolism: regulation and dysregulation. Genes and Nutrition 4: 83-94. PMC2690727 Link PDF
